John A Cook Selected Research

tempol

1/2022	The antioxidant tempol transforms gut microbiome to resist obesity in female C3H mice fed a high fat diet.
8/2015	Selective enhancement of hypoxic cell killing by tempol-regulated suicide gene expression.
5/2015	The nitroxide radical TEMPOL prevents obesity, hyperlipidaemia, elevation of inflammatory cytokines, and modulates atherosclerotic plaque composition in apoE-/- mice.
9/2012	The antioxidant tempol reduces carcinogenesis and enhances survival in mice when administered after nonlethal total body radiation.
7/2012	Pharmacological protection from radiation ± cisplatin-induced oral mucositis.
8/2010	Inhibition of adipogenesis by Tempol in 3T3-L1 cells.
8/2007	Differential radiation protection of salivary glands versus tumor by Tempol with accompanying tissue assessment of Tempol by magnetic resonance imaging.
1/2003	A low molecular weight antioxidant decreases weight and lowers tumor incidence.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

John A Cook Research Topics

Disease

20	Neoplasms (Cancer) 01/2021 - 02/2002
4	Hypoxia (Hypoxemia) 08/2015 - 02/2002
3	Obesity 01/2022 - 08/2010
3	Colonic Neoplasms (Colon Cancer) 01/2021 - 02/2010
3	Carcinogenesis 09/2012 - 01/2003
3	Squamous Cell Carcinoma (Epidermoid Carcinoma) 04/2007 - 02/2002
2	Squamous Cell Carcinoma of Head and Neck 01/2021 - 06/2015
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2021 - 01/2018
2	Hematologic Neoplasms (Hematological Malignancy) 01/2018 - 09/2012
2	Inflammation (Inflammations) 05/2015 - 11/2011
2	Body Weight (Weight, Body) 09/2012 - 08/2010
2	Ulcer 07/2012 - 07/2005
2	Radiation Fibrosis Syndrome (Radiation Fibrosis) 03/2010 - 08/2009
1	Weight Gain 01/2022
1	Atherosclerosis 05/2015
1	Atherosclerotic Plaque (Atheroma) 05/2015
1	Dyslipidemias (Dyslipidemia) 12/2013
1	Liver Diseases (Liver Disease) 08/2013
1	Hepatomegaly 08/2013
1	Lymphoma (Lymphomas) 09/2012
1	Second Primary Neoplasms (Neoplasms, Second) 09/2012
1	Head and Neck Neoplasms (Head and Neck Cancer) 07/2012
1	Stomatitis 07/2012
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2011
1	Weight Loss (Weight Reduction) 08/2010
1	Carcinoma (Carcinomatosis) 02/2010
1	Fibrosis (Cirrhosis) 08/2009
1	Contracture 08/2009
1	Gliosarcoma 04/2007
1	Hyperthermia 07/2004

Drug/Important Bio-Agent (IBA)

8	tempolIBA 01/2022 - 01/2003
7	Oxygen (Dioxygen)IBA 08/2015 - 02/2002
5	AntioxidantsIBA 01/2022 - 01/2003
5	nitroxylIBA 01/2022 - 01/2003
5	carbogenIBA 05/2008 - 02/2002
3	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2011
3	Biomarkers (Surrogate Marker)IBA 01/2021 - 08/2009
2	Fatty Acids (Saturated Fatty Acids)IBA 01/2022 - 08/2013
2	CytokinesIBA 05/2015 - 08/2013
2	Messenger RNA (mRNA)IBA 08/2013 - 04/2007
2	Transforming Growth Factor beta (TGF-beta)IBA 03/2010 - 08/2009
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2022
1	Aldehyde DehydrogenaseIBA 01/2022
1	Bile Acids and Salts (Bile Acids)IBA 01/2022
1	Angiopoietin-Like Protein 4IBA 01/2022
1	NucleotidesIBA 01/2021
1	(2,4- dihydroxy- 5- isopropylphenyl)- (5- (4- methylpiperazin- 1- ylmethyl)- 1,3- dihydroisoindol- 2- yl)methanoneIBA 01/2021
1	Amifostine (Ethyol)FDA LinkGeneric 01/2018
1	abemaciclibIBA 01/2018
1	Pharmaceutical PreparationsIBA 01/2018
1	LuciferasesIBA 08/2015
1	Adenosine Triphosphate (ATP)IBA 06/2015
1	gedatolisibIBA 06/2015
1	AdipokinesIBA 05/2015
1	Apolipoproteins E (ApoE)IBA 05/2015
1	2-aminooxazoleIBA 12/2013
1	AmidesIBA 12/2013
1	AlbuminsIBA 08/2013
1	AcidsIBA 08/2013
1	Transforming Growth Factors (Transforming Growth Factor)IBA 08/2013
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2013
1	CytochromesIBA 08/2013
1	Triglycerides (Triacylglycerol)IBA 08/2013
1	N-caproylglycineIBA 08/2013
1	Phospholipids (Phosphatides)FDA LinkGeneric 08/2013
1	GlobulinsIBA 08/2013
1	N,N-dimethylarginine (asymmetric dimethylarginine)IBA 08/2013
1	Niacinamide (Nicotinamide)FDA LinkGeneric 08/2013
1	Cisplatin (Platino)FDA LinkGeneric 07/2012
1	Methionine (L-Methionine)FDA Link 07/2012
1	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2011
1	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 01/2011
1	Estrogens (Estrogen)FDA Link 01/2011
1	pregna-4,17-diene-3,16-dione (guggulsterone)IBA 01/2011
1	Tamoxifen FDA LinkGeneric 01/2011
1	DNA (Deoxyribonucleic Acid)IBA 01/2011
1	LipidsIBA 08/2010
1	Phosphotransferases (Kinase)IBA 04/2010
1	3- (carbamoylamino)- 5- (3- fluorophenyl)- N- (3- piperidyl)thiophene- 2- carboxamideIBA 04/2010
1	Checkpoint Kinase 1IBA 04/2010
1	Loratadine (Alavert)FDA Link 02/2010
1	Histamine (Histamine Dihydrochloride)FDA Link 02/2010
1	halofuginoneIBA 08/2009
1	Lactic Acid (Lactate)FDA LinkGeneric 05/2008
1	Hydroxylamine (Hydroxylamine Hydrochloride)IBA 08/2007
1	Free RadicalsIBA 08/2007
1	Complementary DNA (cDNA)IBA 04/2007
1	fluoromisonidazoleIBA 04/2007
1	pimonidazoleIBA 04/2007
1	NitroimidazolesIBA 04/2007
1	copper (II) diacetyl- di(N(4)- methylthiosemicarbazone)IBA 04/2007
1	RNA (Ribonucleic Acid)IBA 07/2006
1	Tolonium Chloride FDA Link 07/2005
1	EnzymesIBA 07/2004
1	Glutathione (Reduced Glutathione)IBA 07/2004

Therapy/Procedure

7	Radiotherapy 09/2012 - 07/2004
2	Aftercare (After-Treatment) 07/2006 - 11/2002
2	Electrodes (Electrode) 02/2004 - 05/2002
1	Therapeutics 07/2012
1	Drug Therapy (Chemotherapy) 05/2008